The endocannabinoid system has been shown to play an important role in gut physiology. Are cannabinoids such as CBD effective at treating the symptoms of these disorders?
Cannabinoids are rapidly becoming a new class of respected medicines. Their unique interaction with systems of the body and wide scope of applications make them rockstars within the pharmaceutical and nutraceutical worlds. CBD in particular has risen to popularity as a powerful compound with no psychoactive effects, making it more suitable to a wider range of people.
CBD has been shown to assist with a spectrum of health conditions, achieving many of its effects due to its potent anti-inflammatory properties. The cannabinoid is now showing promise as a treatment for certain conditions that arise in the gut and digestive system.
THE VITAL GUT
In recent years, gut health has become an area of vast importance within the health and wellness spheres. However, this knowledge may only be reappearing, as opposed to being “discovered”. After all, it was Hippocrates who said “All disease begins in the gut”.
It was previously thought that the gut fulfilled only the basic functions of digesting food to release nutrients into the body. Whilst this is an important function indeed, research is beginning to show that the gut’s physiological involvement goes much deeper.
The gut is home to a large portion of what is known as the microbiome, a population of trillions of organisms that exist within and on our bodies. These organisms include bacteria, archaea, eukaryotic parasites, protozoa, and fungi.
The microbiome is fundamental to health. A Harvard report states that microbiota stimulate the immune system, break down potentially toxic food compounds, and synthesise certain vitamins and amino acids such as B vitamins and vitamin K.
A healthy microbiome seems to be key to health, and possibly even happiness. Some of the microbiome is responsible for releasing neurotransmitters, communicating to neurons of the brain in this very way. Such behaviour has given rise to the term “psychobiotics” in regards to some of these organisms. Ever had that weird sensation of a gut feeling? There may be more to this than mere metaphor. Some experts are even labelling the gut the body’s “second brain”.
The link between gut health and mental health may be far stronger than we can imagine. Research has even shown that patients with PTSD have lower than normal levels of some types of gut bacteria.
THE ENDOCANNABINOID SYSTEM WITHIN THE GUT
With gut health being so important, it’s paramount to try and maintain it. Many foods and diets seem to help with this, especially probiotic and cultured foods that serve as vessels to friendly and beneficial bacteria. Cannabinoids such as CBD may also play a key part in supporting gut health.
A paper published within the journal Cannabis and Cannabinoid Research states that cannabis has been used for centuries to treat a variety of disorders associated with the gastrointestinal tract.
The authors add that the endocannabinoid system participates significantly in the normal physiology of gastrointestinal function, displaying involvement in motility, gut-brain-mediated fat intake and hunger signalling, inflammation and gut permeability, and dynamic interactions with gut microbiota.
ENDOCANNABINOID SYSTEM STRUCTURE
The endocannabinoid system is comprised of cell receptor sites found all throughout the body in areas such as the central nervous system, peripheral nervous system, and immune system. So far, two main receptor sites have been identified, known as the CB1 and CB2 receptors.
These sites are also found on cells within the gut and digestive system. Dysregulation of this system may play a role within some intestinal disorders such as inflammatory bowel disease, irritable bowel syndrome, and even obesity.
Cannabinoids are often used as therapeutics that target these receptor sites in conditions involving the endocannabinoid system. These compounds successfully bind or influence receptor sites due to their molecular similarity to endogenous cannabinoids, a phenomenon known as biomimicry. THC is known to bind directly to the CB1 receptors, whereas CBD is known to have an indirect effect upon both the CB1 and CB2 receptors.
CBD AND LEAKY GUT
Some gut problems arise due to issues with gut permeability or “leaky gut”. This issue is associated with numerous autoimmune conditions and chronic health conditions such as chronic fatigue syndrome and multiple sclerosis.
The gut is lined by a barrier of epithelial cells that are linked together by tight junction proteins. These tight junctions are a doorway between your gut and your bloodstream, controlling what passes between them. They allow nutrients to pass through, whilst preventing harmful substances from breaching the gut.
In cases of leaky gut, tight junctions become increasingly permeable and allow access to harmful substances such as bacteria and pathogens. This can result in an inflammatory cascade. There are numerous underlying causes of leaky gut, from chronic stress and genetic predispositions to poor diet and toxin overload. An imbalance in the gut microbiota is also reported to be a cause of the condition.
CBD may be the answer to decreasing the permeability at tight junctions. A paper published within the journal Advanced Research in Gastroenterology & Hepatology states that CBD has been shown to directly restore endothelial membrane permeability. Therefore, the cannabinoid may restore the epithelial integrity of tight junctions.
CBD AND IRRITABLE BOWEL SYNDROME
Irritable bowel syndrome (IBS) is a condition that affects the large intestine of the digestive system, resulting in symptoms such as bloating, diarrhoea, constipation, and stomach cramps.
The condition can be caused by muscle contractions in the intestine, nerve abnormalities in the digestive system, inflammation in the intestines, infection, and changes in the microflora of the gut. Symptoms of IBS can be triggered by several factors such as increased stress, certain foods, and hormonal changes.
Current treatments for IBS include dietary changes, probiotics, and certain medications. However, CBD may be a great addition to this regimen. A paper published within the journal Phytotherapy Research states that evidence indicates cannabis-based products to be effective against IBS.
In regards to CBD, the authors of the paper mention that the cannabinoid’s anti-inflammatory and immunomodulatory effects make it a promising therapeutic agent for treating IBS symptoms like pain and inflammation. The authors conclude CBD to possess an extraordinary range of beneficial effects that may slow the course of IBS and ameliorate symptoms.
CBD may reduce intestinal inflammation severity through the control of what is known as the neuro-immune axis. Enteric glial cells (EGC) mediate both acute and chronic inflammation in the gut. A 2011 paper states that EGC proliferate and release neurotrophins, growth factors, and proinflammatory cytokines which might enhance the immune response, demonstrating a vital link between the nervous and immune systems in the gut.
ECG are responsible for maintaining the integrity of the gut mucosa and play an important role in gut immunity. However, these cells may also generate inflammation. CBD has been shown to control inflammatory response and ECG activation.